Why it matters: This study suggests that serotonergic antidepressants (such as SSRIs and SNRIs) can decrease the effects of psilocybin, the compound responsible for the hallucinogenic properties of magic mushrooms. This is important because psilocybin is gaining traction as a potential treatment for depression, and many people who take antidepressants may be considering psilocybin as an alternative.
What they are saying: The study, which involved a survey of over 2,000 individuals, found that both current users of serotonergic antidepressants and individuals who had stopped taking these medications within the past three months reported weaker effects of psilocybin. This suggests that these antidepressants can reduce the effectiveness of psilocybin therapy.
The big picture: Psilocybin has shown promise as a treatment for depression, with studies indicating significant improvements in symptoms. However, this study suggests that the use of serotonergic antidepressants can interfere with the effectiveness of psilocybin therapy. This raises questions about whether individuals should stop their antidepressant medication before trying psilocybin.
What to watch: It is important for individuals considering psilocybin therapy for depression to be aware that serotonergic antidepressant medications may diminish the effects of psilocybin. They may need to wait up to three months after stopping these medications to fully experience the benefits of psilocybin. More research is needed to better understand the interaction between serotonergic antidepressants and psilocybin.
My take: This study highlights an important consideration for individuals seeking alternative treatments for depression. While psilocybin has shown promise, individuals who are currently taking serotonergic antidepressants should be aware that these medications may reduce its effectiveness. It is advisable to consult with a healthcare professional before making any changes to medication regimens. More research is needed to inform the use of psilocybin in combination with antidepressant medications.
